Written by the British naturalist Alfred Russel Wallace, it chronicles his scientific exploration, during the eight-year period 1854 to 1862, of the southern portion of the Malay Archipelago including Malaysia, Singapore, the islands of Indonesia, then known as the Dutch East Indies, and the island of New Guinea. It was published in two volumes in 1869, delayed by Wallace's ill health and the work needed to describe the many specimens he brought home. The book went through ten editions in the nineteenth century; it has been reprinted many times since, and has been translated into at least eight languages.

The book described each island that he visited in turn, giving a detailed account of its physical and human geography, its volcanoes, and the variety of animals and plants that he found and collected. At the same time, he describes his experiences, the difficulties of travel, and the help he received from the different peoples that he met. The preface notes that he travelled over 14,000 miles and collected 125,660 natural history specimens, mostly of insects though also thousands of molluscs, birds, mammals and reptiles.